Saudi Journal of Gastroenterology

ORIGINAL ARTICLE
Year
: 2012  |  Volume : 18  |  Issue : 4  |  Page : 252--256

Increased protein carbonylation and decreased antioxidant status in anemic H. pylori infected patients: Effect of treatment


Soundravally Rajendiran1, Bobby Zachariah1, Abdoul Hamide2 
1 Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
2 Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India

Correspondence Address:
Bobby Zachariah
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry - 605 006
India

Background/Aim: Collective evidences suggest the causal association of Helicobacter pylori infection with iron deficiency anemia. Generation of free radicals against this bacterium can lead to turbulence in oxidative-antioxidative system. This study was undertaken to evaluate the marker of oxidative protein injury, protein carbonylation, and total antioxidant status in anemic H. pylori0-infected patients and to observe the alteration in them after treatment for 1 month with oral ferrous sulfate and anti-H. pylori therapy. Twenty anemic H. pylori-infected patients were randomly divided into 2 groups. The H. pylori-infected patients in Group I received both iron supplementation and anti-H pylori therapy, whereas patients in Group II received only the iron supplementation. Fifteen healthy volunteers served as controls. All the study parameters were estimated after 1 month of the treatment. Materials and Methods: Protein carbonylation and total antioxidant status were estimated using colorimetric method. Hematologic parameters were evaluated using Sysmex-K-100 automated cell counter. Results: In anemic H. pylori-infected patients, the protein carbonyls (PCOs) were significantly increased, whereas the total antioxidant status, iron, hemoglobin, and ferritin levels were significantly decreased compared with the controls. In Group I, while the PCOs level decreased significantly, there was a significant increase in the total antioxidant status, iron, hemoglobin, and ferritin levels after 1 month. No significant alterations were noted in the levels of PCOs, total antioxidant status, iron, hemoglobin, or ferritin in Group II patients after 1 month of the treatment. Conclusions: The findings from this study indicate that treatment for both anemia and H. pylori infections is required for lowering the oxidative stress markers, which synergistically bring about an appropriate correction of anemia soon in these patients.


How to cite this article:
Rajendiran S, Zachariah B, Hamide A. Increased protein carbonylation and decreased antioxidant status in anemic H. pylori infected patients: Effect of treatment.Saudi J Gastroenterol 2012;18:252-256


How to cite this URL:
Rajendiran S, Zachariah B, Hamide A. Increased protein carbonylation and decreased antioxidant status in anemic H. pylori infected patients: Effect of treatment. Saudi J Gastroenterol [serial online] 2012 [cited 2021 Jun 22 ];18:252-256
Available from: https://www.saudijgastro.com/article.asp?issn=1319-3767;year=2012;volume=18;issue=4;spage=252;epage=256;aulast=Rajendiran;type=0