Saudi Journal of Gastroenterology

REVIEW ARTICLE
Year
: 2016  |  Volume : 22  |  Issue : 1  |  Page : 3--17

The implications of oxidative stress and antioxidant therapies in Inflammatory Bowel Disease: Clinical aspects and animal models


Ioana Miruna Balmus1, Alin Ciobica2, Anca Trifan3, Carol Stanciu5 
1 Department of Biology, Alexandru Ioan Cuza University, Bulevardul Carol, Iaşi, Romania
2 Department of Biology, Alexandru Ioan Cuza University, Bulevardul Carol, Iaşi; Department of Animal Physiology, Center of Biomedical Research of the Romanian Academy, Iaşi, Romania
3 Department of Gastroenterology, "Gr. T. Popa" University of Medicine and Pharmacy, Iaşi, Romania

Correspondence Address:
Dr. Alin Ciobica
Department of Biology, Alexandru Ioan Cuza University, Bulevardul Carol I, 11, Iaşi - 700506
Romania

Inflammatory bowel disease (IBD), including Crohn«SQ»s disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disorder characterized by alternating phases of clinical relapse and remission. The etiology of IBD remains largely unknown, although a combination of patient«SQ»s immune response, genetics, microbiome, and environment plays an important role in disturbing intestinal homeostasis, leading to development and perpetuation of the inflammatory cascade in IBD. As chronic intestinal inflammation is associated with the formation of reactive oxygen and reactive nitrogen species (ROS and RNS), oxidative and nitrosative stress has been proposed as one of the major contributing factor in the IBD development. Substantial evidence suggests that IBD is associated with an imbalance between increased ROS and decreased antioxidant activity, which may explain, at least in part, many of the clinical pathophysiological features of both CD and UC patients. Hereby, we review the presently known oxidant and antioxidant mechanisms involved in IBD-specific events, the animal models used to determine these specific features, and also the antioxidant therapies proposed in IBD patients.


How to cite this article:
Balmus IM, Ciobica A, Trifan A, Stanciu C. The implications of oxidative stress and antioxidant therapies in Inflammatory Bowel Disease: Clinical aspects and animal models.Saudi J Gastroenterol 2016;22:3-17


How to cite this URL:
Balmus IM, Ciobica A, Trifan A, Stanciu C. The implications of oxidative stress and antioxidant therapies in Inflammatory Bowel Disease: Clinical aspects and animal models. Saudi J Gastroenterol [serial online] 2016 [cited 2022 Jan 20 ];22:3-17
Available from: https://www.saudijgastro.com/article.asp?issn=1319-3767;year=2016;volume=22;issue=1;spage=3;epage=17;aulast=Balmus;type=0