Saudi Journal of Gastroenterology

SYSTEMATIC REVIEW/META ANALYSIS
Year
: 2020  |  Volume : 26  |  Issue : 6  |  Page : 299--305

Nonclostridium difficile enteric infection and the risk of developing inflammatory bowel disease: A systematic review and meta-analysis


Cong Dai, Yu-Hong Huang, Min Jiang, Ming-Jun Sun 
 Department of Gastroenterology, First Affiliated Hospital, China Medical University, Shenyang City, Liaoning Province, China

Correspondence Address:
Dr. Cong Dai
No. 92 of Beier Road, Heping District, the City of Shenyang, Liaoning Province - 110 001
China

Background: Inflammatory bowel disease (IBD) is a chronic inflammatory intestinal disorder. Some studies have investigated the association between non-Clostridium difficile infection (CDI) enteric infection and the risk of developing IBD with conflicting conclusions. The objective of our study was to perform a meta-analysis of available studies evaluating the possible association between non-CDI enteric infection and the risk of developing IBD. Methods: We performed a systematic literature search of multiple online electronic databases. Inclusion criteria entailed studies about non-CDI enteric infection and IBD; A meta-analysis was conducted to evaluate relative risk (RR) and 95% confidence intervals (CIs) of combined studies for the association between non-CDI enteric infection and the risk of developing IBD. Publication bias was assessed by funnel plot analysis. Results: Eight studies comprising 345,490 enteric infected patients, 3223 ulcerative colitis (UC) patients, and 2133 CD patients were included in the meta-analysis. Meta-analysis showed a significantly higher risk of UC in patients with enteric infection compared with noninfected patients (RR, 2.28; 95% CI, 1.85–2.8) (I2 = 91.3%, P < 0.001). It also showed a significantly higher risk of CD in patients with enteric infection compared with noninfected patients (RR, 1.88; 95% CI, 1.66–2.14) (I2 = 49%, P = 0.024). Conclusion: Our meta-analysis has found that patients with non-CDI enteric infection were associated with an increased risk of IBD. Future studies are needed to determine the association between non-CDI enteric infection and the risk of developing IBD and elucidate the potential underlying mechanisms.


How to cite this article:
Dai C, Huang YH, Jiang M, Sun MJ. Nonclostridium difficile enteric infection and the risk of developing inflammatory bowel disease: A systematic review and meta-analysis.Saudi J Gastroenterol 2020;26:299-305


How to cite this URL:
Dai C, Huang YH, Jiang M, Sun MJ. Nonclostridium difficile enteric infection and the risk of developing inflammatory bowel disease: A systematic review and meta-analysis. Saudi J Gastroenterol [serial online] 2020 [cited 2021 Jan 24 ];26:299-305
Available from: https://www.saudijgastro.com/article.asp?issn=1319-3767;year=2020;volume=26;issue=6;spage=299;epage=305;aulast=Dai;type=0